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CROSS-LINKING TO AN INTERRUPTED POLYPURINE SEQUENCE WITH A PLATINUM-MODIFIED TRIPLEX-FORMING OLIGONUCLEOTIDE
Triplex-forming oligonucleotides (TFOs) can bind specifically to polypurine sequences in double-stranded DNA. A single interruption of this polypurine tract can greatly destabilize triplex formation. The stability of triplexes can be significantly enhanced by covalently linking the TFO to its DNA ta...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2730491/ https://ncbi.nlm.nih.gov/pubmed/19350290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-009-0499-3 |
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