Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53

Osteopontin (OPN) is highly expressed in cancer patients and plays important roles in many stages of tumor progression, such as anti-apoptosis, proliferation, and metastasis. From functional screening of human cDNA library, we isolated OPN as a caspase-8 substrate that regulates cell death during hy...

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Detalhes bibliográficos
Main Authors: Kim, Hyo-Jin, Lee, Ho-June, Jun, Joon-Il, Oh, Yumin, Choi, Seon-Guk, Kim, Hyunjoo, Chung, Chul-Woong, Kim, In-Ki, Park, Il-Sun, Chae, Han-Jung, Kim, Hyung-Ryong, Jung, Yong-Keun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729277/
https://ncbi.nlm.nih.gov/pubmed/19706414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903704106
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