Mutation I810N in the α3 isoform of Na(+),K(+)-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS

In a mouse mutagenesis screen, we isolated a mutant, Myshkin (Myk), with autosomal dominant complex partial and secondarily generalized seizures, a greatly reduced threshold for hippocampal seizures in vitro, posttetanic hyperexcitability of the CA3-CA1 hippocampal pathway, and neuronal degeneration...

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Detalhes bibliográficos
Main Authors: Clapcote, Steven J., Duffy, Steven, Xie, Gang, Kirshenbaum, Greer, Bechard, Allison R., Rodacker Schack, Vivien, Petersen, Janne, Sinai, Laleh, Saab, Bechara J., Lerch, Jason P., Minassian, Berge A., Ackerley, Cameron A., Sled, John G., Cortez, Miguel A., Henderson, Jeffrey T., Vilsen, Bente, Roder, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729024/
https://ncbi.nlm.nih.gov/pubmed/19666602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904817106
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