Mutation I810N in the α3 isoform of Na(+),K(+)-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS

In a mouse mutagenesis screen, we isolated a mutant, Myshkin (Myk), with autosomal dominant complex partial and secondarily generalized seizures, a greatly reduced threshold for hippocampal seizures in vitro, posttetanic hyperexcitability of the CA3-CA1 hippocampal pathway, and neuronal degeneration...

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Hlavní autoři: Clapcote, Steven J., Duffy, Steven, Xie, Gang, Kirshenbaum, Greer, Bechard, Allison R., Rodacker Schack, Vivien, Petersen, Janne, Sinai, Laleh, Saab, Bechara J., Lerch, Jason P., Minassian, Berge A., Ackerley, Cameron A., Sled, John G., Cortez, Miguel A., Henderson, Jeffrey T., Vilsen, Bente, Roder, John C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729024/
https://ncbi.nlm.nih.gov/pubmed/19666602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904817106
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