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Contribution of Gene Amplification to Evolution of Increased Antibiotic Resistance in Salmonella typhimurium

The use of β-lactam antibiotics has led to the evolution and global spread of a variety of resistance mechanisms, including β-lactamases, a group of enzymes that degrade the β-lactam ring. The evolution of increased β-lactam resistance was studied by exposing independent lineages of Salmonella typhi...

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Main Authors: Sun, Song, Berg, Otto G., Roth, John R., Andersson, Dan I.
Formato: Artigo
Idioma:Inglês
Publicado: Genetics Society of America 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728858/
https://ncbi.nlm.nih.gov/pubmed/19474201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.109.103028
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