Both Paraoxonase-1 Genotype and Activity Do Not Predict the Risk of Future Coronary Artery Disease; the EPIC-Norfolk Prospective Population Study

BACKGROUND: Paraoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether this relation is independent of its carrier...

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Autori principali: Birjmohun, Rakesh S., Vergeer, Menno, Stroes, Erik S. G., Sandhu, Manjinder S., Ricketts, Sally L., Tanck, Michael W., Wareham, Nicholas J., Jukema, J. Wouter, Kastelein, John J. P., Khaw, Kay-Tee, Boekholdt, S. Matthijs
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728540/
https://ncbi.nlm.nih.gov/pubmed/19710913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006809
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