Connective Tissue Growth Factor Overexpression in Cardiomyocytes Promotes Cardiac Hypertrophy and Protection against Pressure Overload

Connective tissue growth factor (CTGF) is a secreted protein that is strongly induced in human and experimental heart failure. CTGF is said to be profibrotic; however, the precise function of CTGF is unclear. We generated transgenic mice and rats with cardiomyocyte-specific CTGF overexpression (CTGF...

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Main Authors: Panek, Anna N., Posch, Maximilian G., Alenina, Natalia, Ghadge, Santhosh K., Erdmann, Bettina, Popova, Elena, Perrot, Andreas, Geier, Christian, Morano, Rainer Dietz Ingo, Bader, Michael, Özcelik, Cemil
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727794/
https://ncbi.nlm.nih.gov/pubmed/19707545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006743
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