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PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T cell responses in EAE

Disease progression in EAE is regulated by PD-1 and its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). B7-H1 and B7-DC, have negative regulatory affects upon binding PD-1 on activated T cells and B7-H1 deficiency increases severity of both diabetes and EAE. However the role of PD-L expression on differen...

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Detalhes bibliográficos
Main Authors: Schreiner, Bettina, Bailey, Samantha L., Shin, Tahiro, Chen, Lieping, Miller, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727707/
https://ncbi.nlm.nih.gov/pubmed/18825752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200838137
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