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Induced pluripotent stem cells and the stability of the differentiated state

For much of the last century, the differentiated state that characterizes the many cell types of an adult organism was thought to be stable and abrogated only in rare instances by transdifferentiation, metaplasia or cancer. This stability was thought to reside in the autoregulatory molecular circuit...

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Autors principals: Colman, Alan, Dreesen, Oliver
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727431/
https://ncbi.nlm.nih.gov/pubmed/19543232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.142
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