Activation of mGluR5 induces spike afterdepolarization and enhanced excitability in medium spiny neurons of the nucleus accumbens by modulating persistent Na(+) currents

The involvement of metabotropic glutamate receptors type 5 (mGluR5) in drug-induced behaviours is well-established but limited information is available on their functional roles in addiction-relevant brain areas like the nucleus accumbens (NAc). This study demonstrates that pharmacological and synap...

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Detalhes bibliográficos
Main Authors: D’Ascenzo, Marcello, Podda, Maria Vittoria, Fellin, Tommaso, Azzena, Gian Battista, Haydon, Philip, Grassi, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727034/
https://ncbi.nlm.nih.gov/pubmed/19433572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.172593
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