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Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure

Sialic acids (Sias) are nonulosonic acid (NulO) sugars prominently displayed on vertebrate cells and occasionally mimicked by bacterial pathogens using homologous biosynthetic pathways. It has been suggested that Sias were an animal innovation and later emerged in pathogens by convergent evolution o...

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Detalhes bibliográficos
Main Authors: Lewis, Amanda L., Desa, Nolan, Hansen, Elizabeth E., Knirel, Yuriy A., Gordon, Jeffrey I., Gagneux, Pascal, Nizet, Victor, Varki, Ajit
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726416/
https://ncbi.nlm.nih.gov/pubmed/19666579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902431106
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