Epistasis between the DAT 3′ UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia

Dopamine has a crucial role in the modulation of neurocognitive function, and synaptic dopamine activity is normally regulated by the dopamine transporter (DAT) and catechol-O-methyltransferase (COMT). Perturbed dopamine function is a key pathophysiological feature of schizophrenia. Our objectives w...

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Detalhes bibliográficos
Main Authors: Prata, Diana P., Mechelli, Andrea, Fu, Cynthia H. Y., Picchioni, Marco, Toulopoulou, Timothea, Bramon, Elvira, Walshe, Muriel, Murray, Robin M., Collier, David A., McGuire, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726372/
https://ncbi.nlm.nih.gov/pubmed/19666577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903007106
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