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AAV-mediated local delivery of interferon-β for the treatment of retinoblastoma in preclinical models

Interferon-β (IFN-β has been found to have anti-tumor properties against a variety of malignancies through different mechanisms. However, clinical trials involving systemic administration of IFN-β have been hampered by secondary toxicity and the short half-life of IFN-β in the circulation. In order...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Shih, Chie-Schin, Laurie, Nikia, Holzmacher, Jeremy, Hu, Yunyu, Nathwani, Amit C., Davidoff, Andrew M., Dyer, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725441/
https://ncbi.nlm.nih.gov/pubmed/19306089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12017-009-8059-0
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