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Identification of a Domain which Affects Kinetics and Antagonistic Potency of Clozapine at 5-HT(3) Receptors
The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT(3) receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT(3) receptors of various species. However, the structural requirements of the respective binding site for...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2725292/ https://ncbi.nlm.nih.gov/pubmed/19696922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006715 |
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