Effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree

A hemodynamic analysis is implemented in the entire coronary arterial tree of diastolically arrested, vasodilated pig heart that takes into account vessel compliance and blood viscosity in each vessel of a large-scale simulation involving millions of vessels. The feed hematocrit (Hct) is varied at t...

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Main Authors: Huo, Yunlong, Kassab, Ghassan S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724323/
https://ncbi.nlm.nih.gov/pubmed/19541733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.91013.2008
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spelling pubmed-27243232010-08-01 Effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree Huo, Yunlong Kassab, Ghassan S. J Appl Physiol (1985) Articles A hemodynamic analysis is implemented in the entire coronary arterial tree of diastolically arrested, vasodilated pig heart that takes into account vessel compliance and blood viscosity in each vessel of a large-scale simulation involving millions of vessels. The feed hematocrit (Hct) is varied at the inlet of the coronary arterial tree, and the Fahraeus-Lindqvist effect and phase separation are considered throughout the vasculature. The major findings are as follows: 1) vessel compliance is the major determinant of nonlinearity of the pressure-flow relation, and 2) changes in Hct influence wall shear stress (WSS) in epicardial coronary arteries more significantly than in transmural and perfusion arterioles because of the Fahraeus-Lindqvist effect. The present study predicts the flow rate as a second-order polynomial function of inlet pressure due to vessel compliance. WSS in epicardial coronary arteries increases >15% with an increase of feed Hct from 45% to 60% and decreases >15% with a decrease of feed Hct from 45% to 30%, whereas WSS in small arterioles is not affected as feed Hct changes in this range. These findings have important implications for acute Hct changes under vasodilated conditions. American Physiological Society 2009-08 2009-06-18 /pmc/articles/PMC2724323/ /pubmed/19541733 http://dx.doi.org/10.1152/japplphysiol.91013.2008 Text en Copyright © 2009, American Physiological Society
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Articles
spellingShingle Articles
Huo, Yunlong
Kassab, Ghassan S.
Effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree
description A hemodynamic analysis is implemented in the entire coronary arterial tree of diastolically arrested, vasodilated pig heart that takes into account vessel compliance and blood viscosity in each vessel of a large-scale simulation involving millions of vessels. The feed hematocrit (Hct) is varied at the inlet of the coronary arterial tree, and the Fahraeus-Lindqvist effect and phase separation are considered throughout the vasculature. The major findings are as follows: 1) vessel compliance is the major determinant of nonlinearity of the pressure-flow relation, and 2) changes in Hct influence wall shear stress (WSS) in epicardial coronary arteries more significantly than in transmural and perfusion arterioles because of the Fahraeus-Lindqvist effect. The present study predicts the flow rate as a second-order polynomial function of inlet pressure due to vessel compliance. WSS in epicardial coronary arteries increases >15% with an increase of feed Hct from 45% to 60% and decreases >15% with a decrease of feed Hct from 45% to 30%, whereas WSS in small arterioles is not affected as feed Hct changes in this range. These findings have important implications for acute Hct changes under vasodilated conditions.
author Huo, Yunlong
Kassab, Ghassan S.
author_facet Huo, Yunlong
Kassab, Ghassan S.
author_sort Huo, Yunlong
title Effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree
title_short Effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree
title_full Effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree
title_fullStr Effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree
title_full_unstemmed Effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree
title_sort effect of compliance and hematocrit on wall shear stress in a model of the entire coronary arterial tree
publisher American Physiological Society
publishDate 2009
url https://ncbi.nlm.nih.gov/pmc/articles/PMC2724323/
https://ncbi.nlm.nih.gov/pubmed/19541733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/japplphysiol.91013.2008
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