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PP2B-dependent NO production in the medullary thick ascending limb during diabetes

Calcineurin (PP2B) has recently been shown to be upregulated in the medullary thick ascending limb (mTAL) during diabetes. The mTAL expresses all three isoforms of nitric oxide synthase (NOS), which are subject to phosphoregulation and represent substrates for PP2B. Therefore, we hypothesized that d...

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Hlavní autoři: Foster, Jan M., Carmines, Pamela K., Pollock, Jennifer S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724259/
https://ncbi.nlm.nih.gov/pubmed/19458119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90760.2008
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