FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1

Fibroblast growth factor-23 (FGF23) is a phosphaturic hormone that contributes to several hypophosphatemic disorders by reducing the expression of the type II sodium-phosphate cotransporters (NaPi-2a and NaPi-2c) in the kidney proximal tubule and by reducing serum 1,25-dihydroxyvitamin D(3) [1,25(OH...

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Hlavní autoři: Gattineni, Jyothsna, Bates, Carlton, Twombley, Katherine, Dwarakanath, Vangipuram, Robinson, Michael L., Goetz, Regina, Mohammadi, Moosa, Baum, Michel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2724258/
https://ncbi.nlm.nih.gov/pubmed/19515808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90742.2008
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