Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography

[Image: see text] We describe a novel fragment library termed fragments of life (FOL) for structure-based drug discovery. The FOL library includes natural small molecules of life, derivatives thereof, and biaryl protein architecture mimetics. The choice of fragments facilitates the interrogation of...

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Autores principales: Davies, Douglas R., Mamat, Bjorn, Magnusson, Olafur T., Christensen, Jeff, Haraldsson, Magnus H., Mishra, Rama, Pease, Brian, Hansen, Erik, Singh, Jasbir, Zembower, David, Kim, Hidong, Kiselyov, Alex S., Burgin, Alex B., Gurney, Mark E., Stewart, Lance J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2009
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722745/
https://ncbi.nlm.nih.gov/pubmed/19618939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900259h
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