B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans

B-cell survival depends on signals induced by B-cell activating factor (BAFF) binding to its receptor (BAFF-R). In mice, mutations in BAFF or BAFF-R cause B-cell lymphopenia and antibody deficiency. Analyzing BAFF-R expression and BAFF-binding to B cells in common variable immunodeficiency (CVID) pa...

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Hauptverfasser: Warnatz, Klaus, Salzer, Ulrich, Rizzi, Marta, Fischer, Beate, Gutenberger, Sylvia, Böhm, Joachim, Kienzler, Anne-Kathrin, Pan-Hammarström, Qiang, Hammarström, Lennart, Rakhmanov, Mirzokhid, Schlesier, Michael, Grimbacher, Bodo, Peter, Hans-Hartmut, Eibel, Hermann
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2009
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722504/
https://ncbi.nlm.nih.gov/pubmed/19666484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903543106
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