A Novel Conus Snail Polypeptide Causes Excitotoxicity by Blocking Desensitization of AMPA Receptors

BACKGROUND: Ionotropic glutamate receptors (iGluRs) are glutamate-gated ion channels that mediate excitatory neurotransmission in the central nervous system. Based on both molecular and pharmacological criteria, iGluRs have been divided into two major classes, the non-NMDA-class, which includes both...

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Main Authors: Walker, Craig S., Jensen, Stori, Ellison, Michael, Matta, Jose A., Lee, Won Yong, Imperial, Julita S., Duclos, Nick, Brockie, Penelope J., Madsen, David M., Isaac, John T. R., Olivera, Baldomero, Maricq, Andres V.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722447/
https://ncbi.nlm.nih.gov/pubmed/19481459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2009.05.017
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