Myocyte necrosis underlies progressive myocardial dystrophy in mouse dsg2-related arrhythmogenic right ventricular cardiomyopathy

Mutations in the cardiac desmosomal protein desmoglein-2 (DSG2) are associated with arrhythmogenic right ventricular cardiomyopathy (ARVC). We studied the explanted heart of a proband carrying the DSG2-N266S mutation as well as transgenic mice (Tg-NS) with cardiac overexpression of the mouse equival...

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Detalhes bibliográficos
Main Authors: Pilichou, Kalliopi, Remme, Carol Ann, Basso, Cristina, Campian, Maria E., Rizzo, Stefania, Barnett, Phil, Scicluna, Brendon P., Bauce, Barbara, van den Hoff, Maurice J.B., de Bakker, Jacques M.T., Tan, Hanno L., Valente, Marialuisa, Nava, Andrea, Wilde, Arthur A.M., Moorman, Antoon F.M., Thiene, Gaetano, Bezzina, Connie R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722163/
https://ncbi.nlm.nih.gov/pubmed/19635863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090641
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