CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

Here, we characterized behavioral abnormalities induced by prolonged social isolation in adult rodents. Social isolation induced both anxiety- and anhedonia-like symptoms and decreased cAMP response element–binding protein (CREB) activity in the nucleus accumbens shell (NAcSh). All of these abnormal...

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Détails bibliographiques
Auteurs principaux: Wallace, Deanna L, Han, Ming-Hu, Graham, Danielle L, Green, Thomas A, Vialou, Vincent, Iñiguez, Sergio D, Cao, Jun-Li, Kirk, Anne, Chakravarty, Sumana, Kumar, Arvind, Krishnan, Vaishnav, Neve, Rachael L, Cooper, Don C, Bolaños, Carlos A, Barrot, Michel, McClung, Colleen A, Nestler, Eric J
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721778/
https://ncbi.nlm.nih.gov/pubmed/19151710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2257
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