Sirolimus affects cardiomyocytes to reduce left ventricular mass in heart transplant recipients

AIMS: The cellular mechanisms underlying cardiac hypertrophy may result from changes in cardiac myocyte growth and differentiation. We tested whether sirolimus, an immunosuppressive agent that inhibits mTOR, a protein that regulates cell division and differentiation, might modify cardiac hypertrophy...

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Detalhes bibliográficos
Main Authors: Kushwaha, Sudhir S., Raichlin, Eugenia, Sheinin, Yuri, Kremers, Walter K., Chandrasekaran, Krishnaswamy, Brunn, Gregory J., Platt, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Clinical Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721707/
https://ncbi.nlm.nih.gov/pubmed/18790727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehn407
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