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Effects of iron depletion on Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) and trophozoite growth: implications for antiamoebic therapy

OBJECTIVES: The purpose of this study was to determine the mechanism by which iron chelation affects the trophozoite survival of Entamoeba histolytica. Fe(2+) is a cofactor for E. histolytica alcohol dehydrogenase 2 (EhADH2), an essential bifunctional enzyme [alcohol dehydrogenase (ADH) and aldehyde...

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Detalhes bibliográficos
Main Authors: Espinosa, Avelina, Perdrizet, George, Paz-y-Miño C., Guillermo, Lanfranchi, Regine, Phay, Monichan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721693/
https://ncbi.nlm.nih.gov/pubmed/19218278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkp015
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