Killing of p53-deficient hepatoma cells by parvovirus H-1 and chemotherapeutics requires promyelocytic leukemia protein

AIM: To evaluate the synergistic targeting and killing of human hepatocellular carcinoma (HCC) cells lacking p53 by the oncolytic autonomous parvovirus (PV) H-1 and chemotherapeutic agents and its dependence on functional promyelocytic leukemia protein (PML). METHODS: The role of p53 and PML in regu...

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Bibliographische Detailangaben
Hauptverfasser: Sieben, Maike, Herzer, Kerstin, Zeidler, Maja, Heinrichs, Vera, Leuchs, Barbara, Schuler, Martin, Cornelis, Jan J, Galle, Peter R, Rommelaere, Jean, Moehler, Markus
Format: Artigo
Sprache:Inglês
Veröffentlicht: The WJG Press and Baishideng 2008
Schlagworte:
Liver Cancer
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721438/
https://ncbi.nlm.nih.gov/pubmed/18609705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.14.3819
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