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Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms?

Folates have a key role in metabolism, and the folate-dependent generation of DNA precursors in the form of deoxythymidine 5′-phosphate is particularly important for the replication of malaria parasites. Although Plasmodium falciparum can synthesize folate derivatives de novo, a long-standing myster...

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Autors principals: Hyde, John E., Dittrich, Sabine, Wang, Ping, Sims, Paul F.G., de Crécy-Lagard, Valérie, Hanson, Andrew D.
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720532/
https://ncbi.nlm.nih.gov/pubmed/18805734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pt.2008.08.004
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