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Alternative mRNA Splicing of SMRT Creates Functional Diversity by Generating Corepressor Isoforms with Different Affinities for Different Nuclear Receptors

Many eukaryotic transcription factors are bimodal in their regulatory properties and can both repress and activate expression of their target genes. These divergent transcriptional properties are conferred through recruitment of auxiliary proteins, denoted coactivators and corepressors. Repression p...

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Detalhes bibliográficos
Main Authors: Goodson, Michael L., Jonas, Brian A., Privalsky, Martin L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720035/
https://ncbi.nlm.nih.gov/pubmed/15632172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M411514200
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