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The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice

Recombinant adeno-associated viruses (AAVs) have been used widely for in vivo gene therapy. However, adaptive immune responses to AAV have posed a significant hurdle in clinical application of AAV vectors. Recent advances have suggested a crucial role for innate immunity in shaping adaptive immune r...

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書誌詳細
主要な著者: Zhu, Jiangao, Huang, Xiaopei, Yang, Yiping
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719948/
https://ncbi.nlm.nih.gov/pubmed/19587448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37607
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