The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8(+) T cells

CTLs eliminate virus-infected and tumorigenic cells through exocytosis of cytotoxic agents from lytic granules. While insights into the intracellular mechanisms facilitating lytic granule release have been obtained through analysis of loss-of-function mutations in humans and mice, there is a paucity...

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Main Authors: Rüder, Constantin, Höpken, Uta E., Wolf, Jana, Mittrücker, Hans-Willi, Engels, Boris, Erdmann, Bettina, Wollenzin, Susanne, Uckert, Wolfgang, Dörken, Bernd, Rehm, Armin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719940/
https://ncbi.nlm.nih.gov/pubmed/19620783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37760
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