CCR6 is required for IL-23–induced psoriasis-like inflammation in mice

Psoriasis is a common immune-mediated chronic inflammatory skin disorder, but the mechanisms of pathogenesis are still poorly understood. IL-23 is expressed in psoriatic skin, and IL-23 injection produces IL-22–dependent psoriasiform changes in mouse skin. Th17 cells produce IL-22 and display CCR6,...

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Main Authors: Hedrick, Michael N., Lonsdorf, Anke S., Shirakawa, Aiko-Konno, Lee, Chyi-Chia Richard, Liao, Fang, Singh, Satya P., Zhang, Hongwei H., Grinberg, Alexander, Love, Paul E., Hwang, Sam T., Farber, Joshua M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719919/
https://ncbi.nlm.nih.gov/pubmed/19662682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37378
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