Crystal Structure of a Fibroblast Growth Factor Homologous Factor (FHF) Defines a Conserved Surface on FHFs for Binding and Modulation of Voltage-gated Sodium Channels

Voltage-gated sodium channels (Na(v)) produce sodium currents that underlie the initiation and propagation of action potentials in nerve and muscle cells. Fibroblast growth factor homologous factors (FHFs) bind to the intracellular C-terminal region of the Na(v) α subunit to modulate fast inactivati...

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Detalhes bibliográficos
Main Authors: Goetz, Regina, Dover, Katarzyna, Laezza, Fernanda, Shtraizent, Nataly, Huang, Xiao, Tchetchik, Dafna, Eliseenkova, Anna V., Xu, Chong-Feng, Neubert, Thomas A., Ornitz, David M., Goldfarb, Mitchell, Mohammadi, Moosa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719427/
https://ncbi.nlm.nih.gov/pubmed/19406745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.001842
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