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Phosphorylation and Protein-protein Interactions in PXR-mediated CYP3A Repression
BACKGROUND: The expression of drug-metabolizing enzymes cytochrome P450 (CYPs) is controlled by pregnane X receptor (PXR), and therefore understanding how PXR modulates CYP expression is important to minimize adverse drug interactions, one type of preventable adverse drug reaction. OBJECTIVE: We rev...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2719259/ https://ncbi.nlm.nih.gov/pubmed/19505191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/17425250903012360 |
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