High-dose methotrexate for elderly patients with primary CNS lymphoma

The introduction of methotrexate (MTX)-based chemotherapy has improved median survival for patients with primary CNS lymphoma (PCNSL). Older age is a negative prognostic marker in patients with PCNSL and may increase the likelihood of MTX toxicity. We studied the response and adverse effects of intr...

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Bibliographic Details
Main Authors: Zhu, Jay-Jiguang, Gerstner, Elizabeth R., Engler, David A., Mrugala, Maciej M., Nugent, Whitney, Nierenberg, Kristin, Hochberg, Fred H., Betensky, Rebecca A., Batchelor, Tracy T.
Format: Artigo
Language:Inglês
Published: Duke University Press 2009
Subjects:
Clinical Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718993/
https://ncbi.nlm.nih.gov/pubmed/18757775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2008-067
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