Kinetic and Thermodynamic Characterization of Dihydrotestosterone-Induced Conformational Perturbations in Androgen Receptor Ligand-Binding Domain

Ligand-induced conformational perturbations in androgen receptor (AR) are important in coactivator recruitment and transactivation. However, molecular rearrangements in AR ligand-binding domain (AR-LBD) associated with agonist binding and their kinetic and thermodynamic parameters are poorly underst...

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Autors principals: Jasuja, Ravi, Ulloor, Jagadish, Yengo, Christopher M., Choong, Karen, Istomin, Andrei Y., Livesay, Dennis R., Jacobs, Donald J., Swerdloff, Ronald S., Mikšovská, Jaroslava, Larsen, Randy W., Bhasin, Shalender
Format: Artigo
Idioma:Inglês
Publicat: The Endocrine Society 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718745/
https://ncbi.nlm.nih.gov/pubmed/19443608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0304
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