Polymorphisms and Haplotypes of Acid Mammalian Chitinase Are Associated with Bronchial Asthma

Rationale: Chitinases are enzymes that cleave chitin, a polysaccharide contained in many parasites of humans. Recent studies in mouse models of bronchial asthma have shown that acid mammalian chitinase (AMCase) is involved in the pathophysiology of asthma. It acts downstream of interleukin-13; inhib...

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Bibliografiske detaljer
Main Authors: Bierbaum, Sibylle, Nickel, Renate, Koch, Anja, Lau, Susanne, Deichmann, Klaus A., Wahn, Ulrich, Superti-Furga, Andrea, Heinzmann, Andrea
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2005
Fag:
A. Asthma and Allergy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718453/
https://ncbi.nlm.nih.gov/pubmed/16179638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200506-890OC
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