Polymorphisms and Haplotypes of Acid Mammalian Chitinase Are Associated with Bronchial Asthma

Rationale: Chitinases are enzymes that cleave chitin, a polysaccharide contained in many parasites of humans. Recent studies in mouse models of bronchial asthma have shown that acid mammalian chitinase (AMCase) is involved in the pathophysiology of asthma. It acts downstream of interleukin-13; inhib...

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Bibliografiska uppgifter
Huvudupphovsmän: Bierbaum, Sibylle, Nickel, Renate, Koch, Anja, Lau, Susanne, Deichmann, Klaus A., Wahn, Ulrich, Superti-Furga, Andrea, Heinzmann, Andrea
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Thoracic Society 2005
Ämnen:
A. Asthma and Allergy
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718453/
https://ncbi.nlm.nih.gov/pubmed/16179638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200506-890OC
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