Polymorphisms and Haplotypes of Acid Mammalian Chitinase Are Associated with Bronchial Asthma

Rationale: Chitinases are enzymes that cleave chitin, a polysaccharide contained in many parasites of humans. Recent studies in mouse models of bronchial asthma have shown that acid mammalian chitinase (AMCase) is involved in the pathophysiology of asthma. It acts downstream of interleukin-13; inhib...

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Detalhes bibliográficos
Main Authors: Bierbaum, Sibylle, Nickel, Renate, Koch, Anja, Lau, Susanne, Deichmann, Klaus A., Wahn, Ulrich, Superti-Furga, Andrea, Heinzmann, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2005
Assuntos:
A. Asthma and Allergy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718453/
https://ncbi.nlm.nih.gov/pubmed/16179638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200506-890OC
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