Polymorphisms and Haplotypes of Acid Mammalian Chitinase Are Associated with Bronchial Asthma

Rationale: Chitinases are enzymes that cleave chitin, a polysaccharide contained in many parasites of humans. Recent studies in mouse models of bronchial asthma have shown that acid mammalian chitinase (AMCase) is involved in the pathophysiology of asthma. It acts downstream of interleukin-13; inhib...

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Hlavní autoři: Bierbaum, Sibylle, Nickel, Renate, Koch, Anja, Lau, Susanne, Deichmann, Klaus A., Wahn, Ulrich, Superti-Furga, Andrea, Heinzmann, Andrea
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2005
Témata:
A. Asthma and Allergy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718453/
https://ncbi.nlm.nih.gov/pubmed/16179638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200506-890OC
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