A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway

The Drosophila Toll receptor does not interact directly with microbial determinants, but is instead activated by a cleaved form of the cytokine-like molecule Spätzle. During the immune response, Spätzle is processed by complex cascades of serine proteases, which are activated by secreted pattern-rec...

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Bibliografske podrobnosti
Main Authors: Buchon, Nicolas, Poidevin, Mickael, Kwon, Hyun-Mi, Guillou, Aurélien, Sottas, Valentin, Lee, Bok-Luel, Lemaitre, Bruno
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718337/
https://ncbi.nlm.nih.gov/pubmed/19590012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901924106
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