Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1

Phosphoglycerate mutase (PGAM) is an enzyme of intermediary metabolism that converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis. Here, we discovered PGAM5 that is anchored in the mitochondrial membrane lacks PGAM activity and instead associates with the MAP kinase kinase kinase ASK1 and...

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Detalhes bibliográficos
Main Authors: Takeda, Kohsuke, Komuro, Yoshiko, Hayakawa, Teruyuki, Oguchi, Haruka, Ishida, Yosuke, Murakami, Shiori, Noguchi, Takuya, Kinoshita, Hideyuki, Sekine, Yusuke, Iemura, Shun-ichiro, Natsume, Tohru, Ichijo, Hidenori
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718331/
https://ncbi.nlm.nih.gov/pubmed/19590015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901823106
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