Cardiac Myosin Binding Protein-C Is Essential for Thick-Filament Stability and Flexural Rigidity

Using atomic force microscopy, we examined the contribution of cardiac myosin binding protein-C (cMyBP-C) to thick-filament length and flexural rigidity. Native thick filaments were isolated from the hearts of transgenic mice bearing a truncation mutation of cMyBP-C (t/t) that results in no detectab...

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Autors principals: Nyland, Lori R., Palmer, Bradley M., Chen, Zengyi, Maughan, David W., Seidman, Christine E., Seidman, J.G., Kreplak, Laurent, Vigoreaux, Jim O.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2009
Matèries:
Muscle, Molecular Motors, and Cell Motility
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718271/
https://ncbi.nlm.nih.gov/pubmed/19383471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.12.3946
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