In Vivo Interaction of Steroid Receptor Coactivator (SRC)-1 and the Activation Function-2 Domain of the Thyroid Hormone Receptor (TR) β in TRβ E457A Knock-In and SRC-1 Knockout mice

The activation function-2 (AF-2) domain of the thyroid hormone (TH) receptor (TR)-β is a TH-dependent binding site for nuclear coactivators (NCoA), which modulate TH-dependent gene transcription. In contrast, the putative AF-1 domain is a TH-independent region interacting with NCoA. We determined th...

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Bibliographic Details
Main Authors: Alonso, Manuela, Goodwin, Charles, Liao, XiaoHui, Ortiga-Carvalho, Tania, Machado, Danielle S., Wondisford, Fredric E., Refetoff, Samuel, Weiss, Roy E.
Format: Artigo
Language:Inglês
Published: The Endocrine Society 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717870/
https://ncbi.nlm.nih.gov/pubmed/19406944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-0093
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