Antibody Titer Threshold Predicts Anti-Candidal Vaccine Efficacy Even though the Mechanism of Protection Is Induction of Cell-Mediated Immunity

We previously reported that vaccination with Freund’s adjuvant plus the recombinant N-terminus of the candidal adhesin, Als3p (rAls3p-N), protects mice from disseminated candidiasis. Here we report that the rAls3p-N vaccine is effective when combined with aluminum hydroxide adjuvant. Antibody titers...

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Detalhes bibliográficos
Main Authors: Spellberg, Brad, Ibrahim, Ashraf S., Lin, Lin, Avanesian, Valentina, Fu, Yue, Lipke, Peter, Otoo, Henry, Ho, Tiffany, Edwards, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717621/
https://ncbi.nlm.nih.gov/pubmed/18419471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/529204
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