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Cross-Correlated TIRF/AFM Reveals Asymmetric Distribution of Force-Generating Heads along Self-Assembled, “Synthetic” Myosin Filaments

Myosin-II's rod-like tail drives filament assembly with a head arrangement that is often considered to be a symmetric bipole that generates equal and opposite contractile forces on actin. Self-assembled myosin filaments are shown here to be asymmetric in physiological buffer based on cross-corr...

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Detalhes bibliográficos
Principais autores: Brown, André E.X., Hategan, Alina, Safer, Daniel, Goldman, Yale E., Discher, Dennis E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717282/
https://ncbi.nlm.nih.gov/pubmed/19254555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.11.032
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