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The Small Organic Compound HMN-176 Delays Satisfaction of the Spindle Assembly Checkpoint by Inhibiting Centrosome-Dependent Microtubule Nucleation

HMN-176 is a potential new cancer therapeutic known to retard the proliferation of tumor cell lines. Here we show this compound inhibits meiotic spindle assembly in surf clam oocytes and delays satisfaction of the spindle assembly checkpoint in human somatic cells by inducing the formation of short...

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Bibliografiska uppgifter
Huvudupphovsmän: DiMaio, Michael A., Mikhailov, Alexei, Rieder, Conly L., Von Hoff, Daniel D., Palazzo, Robert E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717217/
https://ncbi.nlm.nih.gov/pubmed/19258425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-08-0876
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