Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-β1 in Renal Tubular Epithelial Cells

Epithelial-mesenchymal transition (EMT) plays an important role in organ fibrosis, including that of the kidney. Loss of E-cadherin expression is a hallmark of EMT; however, whether the loss of E-cadherin is a consequence or a cause of EMT remains unknown, especially in the renal system. In this stu...

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Detalhes bibliográficos
Main Authors: Zheng, Guoping, Lyons, James Guy, Tan, Thian Kui, Wang, Yiping, Hsu, Tzu-Ting, Min, Danqing, Succar, Lena, Rangan, Gopala K., Hu, Min, Henderson, Beric R., Alexander, Stephen I., Harris, David C.H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716958/
https://ncbi.nlm.nih.gov/pubmed/19590041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080983
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