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Intramembrane Water Associated with TOAC Spin-Labeled Alamethicin: Electron Spin-Echo Envelope Modulation by D(2)O

Alamethicin is a 20-residue, hydrophobic, helical peptide, which forms voltage-sensitive ion channels in lipid membranes. The helicogenic, nitroxyl amino acid TOAC was substituted isosterically for Aib at residue positions 1, 8, or 16 in a F50/5 alamethicin analog to enable EPR studies. Electron spi...

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Autors principals: Bartucci, R., Guzzi, R., Sportelli, L., Marsh, D.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716648/
https://ncbi.nlm.nih.gov/pubmed/19186137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.024
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