Fold-Unfold Transitions in the Selectivity and Mechanism of Action of the N-Terminal Fragment of the Bactericidal/Permeability-Increasing Protein (rBPI(21))

Septic or endotoxic shock is a common cause of death in hospital intensive care units. In the last decade numerous antimicrobial peptides and proteins have been tested in the search for an efficient drug to treat this lethal disease. Now in phase III clinical trials, rBPI(21), a recombinant N-termin...

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Detalhes bibliográficos
Main Authors: Domingues, Marco M., Lopes, Sílvia C.D.N., Santos, Nuno C., Quintas, Alexandre, Castanho, Miguel A.R.B.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2009
Assuntos:
Membrane
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716647/
https://ncbi.nlm.nih.gov/pubmed/19186136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.044
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