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Computational Modeling of Structurally Conserved Cancer Mutations in the RET and MET Kinases: The Impact on Protein Structure, Dynamics, and Stability

Structural and biochemical characterization of protein kinases that confer oncogene addiction and harbor a large number of disease-associated mutations, including RET and MET kinases, have provided insights into molecular mechanisms associated with the protein kinase activation in human cancer. In t...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Dixit, Anshuman, Torkamani, Ali, Schork, Nicholas J., Verkhivker, Gennady
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The Biophysical Society 2009
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716637/
https://ncbi.nlm.nih.gov/pubmed/19186126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.041
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