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Differential Effects of Phosphorylation of Regions of Troponin I in Modifying Cooperative Activation of Cardiac Thin Filaments

Ischemia and heart failure are associated with protein kinase C (PKC) dependent phosphorylation of cardiac troponin I (cTnI). We investigated the effect of phosphorylation of cTnI PKC sites S43, S45 and T144 under normal (pH 7.0) and acidic (pH 6.5) conditions on tension in skinned fiber bundles fro...

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書誌詳細
主要な著者: Engel, Patti L., Hinken, Aaron, Solaro, R. John
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716429/
https://ncbi.nlm.nih.gov/pubmed/19426736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2009.04.016
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