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Phosphatidylinositol 3 Kinase Pathway and 4-Hydroxy-2-Nonenal-Induced Oxidative Injury in the RPE

PURPOSE: 4-Hydroxy-2-nonenal (4-HNE) is a major lipid peroxidation product in the retina and the retinal pigment epithelium. The purpose of the present study was to investigate how NF-E2–related factor-2 (Nrf2) and phosphatidylinositol 3 (PI3K) pathways affect the responses of cultured human retinal...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chen, Jianbin, Wang, Ling, Chen, Yan, Sternberg, Paul, Cai, Jiyang
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716057/
https://ncbi.nlm.nih.gov/pubmed/18806289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.08-2439
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