Intrapulmonary Delivery of XCL1-Targeting Small Interfering RNA in Mice Chronically Infected with Mycobacterium tuberculosis

Mice infected for 60 days with Mycobacterium tuberculosis were treated with aerosolized XCL1-targeting small interfering RNA (siRNA) to induce local and transient suppression of XCL1/lymphotactin (an important chemokine in tuberculoid granuloma formation). The local pulmonary siRNA therapy resulted...

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Detalhes bibliográficos
Main Authors: Rosas-Taraco, Adrian G., Higgins, David M., Sánchez-Campillo, Joaquín, Lee, Eric J., Orme, Ian M., González-Juarrero, Mercedes
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715903/
https://ncbi.nlm.nih.gov/pubmed/19097989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2008-0363OC
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