Diabetic β-Cells Can Achieve Self-Protection against Oxidative Stress through an Adaptive Up-Regulation of Their Antioxidant Defenses

BACKGROUND: Oxidative stress (OS), through excessive and/or chronic reactive oxygen species (ROS), is a mediator of diabetes-related damages in various tissues including pancreatic β-cells. Here, we have evaluated islet OS status and β-cell response to ROS using the GK/Par rat as a model of type 2 d...

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Detalhes bibliográficos
Main Authors: Lacraz, Grégory, Figeac, Florence, Movassat, Jamileh, Kassis, Nadim, Coulaud, Josiane, Galinier, Anne, Leloup, Corinne, Bailbé, Danielle, Homo-Delarche, Françoise, Portha, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715861/
https://ncbi.nlm.nih.gov/pubmed/19654863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006500
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