Loss of MicroRNA Targets in the 3′ Untranslated Region as a Mechanism of Retroviral Insertional Activation of Growth Factor Independence 1

The non-oncogene-bearing retrovirus SL3-3 murine leukemia virus induces strictly T-cell lymphomas with a mean latency of 2 to 4 months in mice of the NMRI-inbred (NMRI-i) strain. By high-throughput sequencing of retroviral tags, we have identified the genomic region carrying the transcriptional repr...

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Hlavní autoři: Dabrowska, Magdalena Julia, Dybkaer, Karen, Johnsen, Hans Erik, Wang, Bruce, Wabl, Matthias, Pedersen, Finn Skou
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
Transformation and Oncogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715787/
https://ncbi.nlm.nih.gov/pubmed/19474094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00427-09
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